CIP vs. SIP Systems in Industrial Bioprocessing

Ce site est optimisé pour être consulté depuis un navigateur moderne dans lequel JavaScript est activé.

CIP vs. SIP Systems in Industrial Bioprocessing

gasser

Hi everyone! I’m working on scaling up a bioprocess from lab to industrial production and need advice on Clean-in-Place (CIP) and Steam-in-Place (SIP) systems. We’re using stainless steel bioreactors (1000L+), and I want to optimize cleaning and sterilization cycles to ensure regulatory compliance (GMP/FDA).

Which CIP parameters (flow rate, temperature, chemical concentration) work best for industrial-scale bioreactors?

daruma

Hi! I recently scaled up to industrial bioreactors (1000L+), and we integrated CIP/SIP systems for efficient cleaning and sterilization. I found the CIP / SIP Systems for Industry to be crucial for ensuring compliance with GMP/FDA standards. For industrial-scale, optimizing flow rate, temperature, and chemical concentration is key. Typically, flow rates of 1-2 m/s, temperatures of 80-95°C, and 0.5-2% concentration of cleaning agents work well. I highly recommend using automated CIP cycles to reduce manual handling and ensure consistent results across large systems.

greyder

Thanks for the insights! We’re producing monoclonal antibodies, so we need strict endotoxin control. We’re using direct steam injection for SIP, but I’m worried about dead zones in pipework.

Would adding a pulsed steam sequence help improve sterilization coverage?